In contrast, virus infection significantly increased expression levels of both thio-ester containing protein 22 (TEP22) and the Niemann–Pick type C1 (NPC1) transcripts in Ae. albopictus, whereas the expression of these two genes was slightly affected in infected Ae. aegypti (Figure 4): In infected Ae. albopictus midgut, the expression of NPC1 was significantly higher (10-fold induction) as compared to the expression of the same gene in infected Ae. aegypti midgut (2-fold induction). The gene discussed is NPC1; the disease is viral infectious disease.