As shown in Figure 9E, the expression of caspase-3 was increased in the polysaccharide group at all tested doses and in the combination group, and the expression of the low-dose combination group was similar to that of the DDP group, suggesting that the mitochondria-mediated apoptotic pathway might be involved in AX-I-3b-induced apoptosis in mouse tumor cells. This evidence concerns the gene CASP3 and neoplasm.