ADAM10 and systemic lupus erythematosus: Ectodomain shedding of the transmembrane receptor tyrosine kinase Axl from systemic lupus erythematosus (SLE) leukocytes was mediated by ADAM10 and 17 in systemic lupus erythematosus [100] and it is conceivable that sAxl levels during acute and chronic liver disease correlate with ADAM10/17 activity in the liver.