For us, the most interesting finding of this study was that NLRP1 rs12150220 exhibited a statistically significant association with lung function, where minor allele carriers had a decreased FEV1% and FEV1/FVC ratio, together with, to some extent, elevated serum IL-1β-clinical conditions, which have been strongly correlated with worse COPD prognosis [22]. The gene discussed is NLRP1; the disease is chronic obstructive pulmonary disease.