Logistic regression analysis, adjusted for age, gender, and smoking history, indicated only a nominal association with COPD risk for two SNPs in dominant model: NLRP1 SNP rs12150220_AT (A/T OR = 0.54, p = 0.03; T/T OR = 0.59, p = 0.17; A/T + T/T OR = 0.55, p = 0.03) and NLRP4 SNP rs12462372_AG (A/G OR = 0.36, p = 0.03; A/A OR = 0.29, p = 0.77; A/G + A/A OR = 0.36, p = 0.03), suggesting that there is no association between the tested SNPs and COPD risk (Table 4). This evidence concerns the gene NLRP4 and chronic obstructive pulmonary disease.