MLXIPL and cancer: It is thought that ChREBP upregulates glycolysis since it increases the mRNA contents of several glycolytic proteins such as GLUTs (2,4,5), HPI, ALDO, GAPDH, and PYK-L (liver isoform) in normal (rat hepatocytes) [148] and PYK-LR (liver and red cell isoforms) cancer (HepG2) cells (Figure 1, Table 2), although the glycolytic flux has not been evaluated.