The activation of the androgen receptor (AR) with a synthetic androgenic agonist (R1881) in the human androgen-dependent prostate cancer cells LNCaP and LAPC4 promotes an increase in mRNA levels of Krebs cycle enzymes (FH, 2OGDH), ATPS, and ND1, as well as OxPhos flux (Figure 2A, Table 3). This evidence concerns the gene AR and Familial prostate cancer.