PPARGC1A and metastatic prostate carcinoma: PGC1α overexpression also increases the (i) mRNA contents of SDH, IDH3, and cytosolic aspartate aminotransferase; (ii) β-oxidation flux; (iii) the contents of the Krebs cycle intermediates OAA, fumarate, and L-malate; and (iv) ATP intracellular content in metastatic prostate cancer PC3 cells versus nonexpressing PGC1α cells (Figure 2, Table 3).