In the human androgen-dependent prostate cancer cells LNCaP and LAPC4, AR activation with the synthetic androgen R1881 increases the HKII, PFK-platelet isoform, ENO, and PGK mRNA contents versus nontreated cells (Figure 1, Table 2), as well as the glycolytic rate, which is measured as the extracellular acidification rate (Table 2). This evidence concerns the gene HK2 and Familial prostate cancer.