The homotetrameric tumor suppressor p53 protein, coded by the TP53 gene, has 12 different isoforms (p53α, p53β, Δ40p53γ, Δ133p53α, Δ133p53β, Δ133p53γ, Δ160p53α, Δ160p53β, and Δ160p53γ), and p53α is the most abundant and well-studied [77]: p53 acts as a TF of several cellular processes associated with cancer suppression (Table 1). The gene discussed is TP53; the disease is cancer.