KRAS and neoplasm: In support of this, multivariate Cox regression analyses revealed that KRAS status (mutant vs. WT) at diagnosis influenced OS (hazard ratio (HR) 0.645, 95% confidence interval (CI) 0.458–0.908, p =  0.012) and PFS (HR 0.597, 95% CI 0.402–0.887, p =  0.011) independently from age (continuous; P values were 0.081 and 0.628, respectively), gender (female vs. male; p values were 0.005 and 0.001, respectively), smoking status (never vs. ever; p values were 0.907 and 0.835, respectively), ECOG PS (0 vs. 1; P values were 0.193 and 0.177, respectively) and tumor stage (III.