In addition, resveratrol can activate ERK1/2 and induce accumulation of nuclear cyclooxygenase (COX-2) via directing interaction with the integrin αvβ3 receptor to further induce phosphorylation of ERK1/2, which translocates into the cell nucleus and complexes with inducible COX-2 in resveratrol treatment cancer cells. This evidence concerns the gene MAPK3 and cancer.