The common upregulated genes in metastasis and primary tumor include epiphycan (EPYC), collagen type X alpha chain 1 (COL10A1), fibronectin type III domain containing 1 (FNDC1) and podocan-like protein I (PODNL1), which are mainly extracellular matrix related genes. The gene discussed is PODNL1; the disease is neoplasm.