MAT1A and urinary bladder neoplasm: Figure 3D illustrates the typical IHC pattern observed for patients sample with both cytoplasmic and nuclear staining, while Figure 3E illustrates human samples with predominant cytoplasmic staining. However, our findings revealed that 100% of the patient samples with reported neoadjuvant chemotherapy had some level of MAT1A protein expression, suggesting that MAT1A protein expression correlates with chemotherapy treatment in human bladder tumors.