RPS19 and Diamond-Blackfan anemia: However, this trial ended up with embryonic lethality for mice harboring homozygous loss of Rps19 and a normal hematopoietic phenotype for mice harboring heterozygous loss of Rps19. Four years later, another mouse model of DBA was developed that carries a heterozygous missense mutation in Rps19 (Dsk3 mutant).