Furthermore, it was recently demonstrated that uncontrolled glycolysis in TECs due to an upregulated expression of glycolysis genes, including the enzyme 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 (PFKFB3), contributes to structural deformities observed in tumor blood vessels [19]. Here, PFKFB3 is linked to neoplasm.