In conclusion, we demonstrated in the current study, that nanosuspension-formulated honokiol provides protective effects against cisplatin-induced kidney damages in vivo, and these protective outcomes and the improvement of renal functions were likely resulted from the combined effects of: (1) reduced cellular oxidative stress, (2) restoration of mitochondria function and integrity, and (3) reduced caspase 3-associated apoptosis, all these above-mentioned consequences resulted in the improved renal physiology of cisplatin-treated animals and mitigated cisplatin-induced nephrotocixity. The gene discussed is CASP3; the disease is Nephropathy.