Notably, germline CDH1 c.88C>A has been reported in lobular breast carcinoma and diffuse-type GC patients, as well as in two unrelated individuals with cleft lip with or without cleft palate, a developmental birth defect that is known to be overrepresented in CDH1 mutation carriers [31,32,33,34]. This evidence concerns the gene CDH1 and cleft palate.