CD274 and neoplasm: However, it was observed in the study by Mariathasan S et al. Tauriello DVF et al., using murine models that exhibited an immune-excluded phenotype, that co-administration of TGF-β and PDL1 blocking antibodies, as compared to monotherapies, reduced TGF-β signaling facilitating T cell penetration in tumors and provoked a robust anti-tumor immunity which led to regression of the tumor.