Phosphorylation by IKKβ targets IκBα for proteasomal degradation, which liberates NF-κB for translocation into the nucleus, where it initiates the transcription of various genes involved in insulin resistance, such as growth factors, cytokine genes (IL-1, IL-6, IL-8, and TNF-α), adhesion molecules, and proteins in the acute phase. This evidence concerns the gene IKBKB and Insulin resistance.