Concretely, it has been shown that de novo synthesized steroids by cancer cells play an important role in the establishment of metastasis and the induction of castration resistance in PC cells by affecting androgen receptor positive cells in the tumour microenvironment, this is in stroma fibroblasts, smooth muscle cells, endothelial cells, osteoblasts, and inflammatory cells. The gene discussed is AR; the disease is pachyonychia congenita.