CSF2 and myeloid sarcoma: The altered expression of cytokines and inflammatory mediators such as granulocyte-macrophage colony-stimulating factor (GM-CSF) [22], interferon- β (IFN-β) [23,24] and interlukin-17 (IL-17) [25] in human MS, as well as IFN-γ [26], IL-1β [27], IL-10 [28], IL-12 [29], IL-23 [30] and tumour necrosis factor-α (TNF-α) [31] in EAE models have been significantly correlated with neuroinflammation.