IL6 and cancer: Since the secretion of several factors from MSCs is a key component of cancer progression [42,43], we evaluated in the conditioned media of BM-MSCs stimulated with small EVs derived from OCS the levels of three factors (interluekin-6 (IL-6), interleukin-8 (IL-8), and vascular endothelial growth factor A (VEGFA)) involved in pro-tumorigenic processes.