Our work was done using a normal colonic fibroblast cell line, which supports our final conclusion, as there are reports showed that preexisting normal stromal fibroblasts could potentially convert into myofibroblasts in response to TGF‐β in vivo, specifically during the course of tumor progression (Kojima et al., 2010; Midgley et al., 2013). This evidence concerns the gene TGFB1 and neoplasm.