ERBB2 and colonic neoplasm: In CRC cells, the role of α5β1 is controversial, as some studies showed that α5β1 is required for colon cancer cell survival, invasion and migration (Lee and Juliano, 2000; Murillo et al., 2004), whereas in another study α5β1 exerted its tumor suppressor‐like activity in colon cancer cells by inhibiting HER‐2 signaling (Kuwada et al., 2005).