Interestingly, Kuninty et al. (2018) recently reported that α5 integrin could also contribute to tumor‐promoting effects of pancreatic stellate cells in pancreatic cancer, and revealed α5 as a therapeutic target in pancreatic cancer, which suggested a ubiquitous role of α5 expressed on fibroblasts to promote tumorigenesis. This evidence concerns the gene IGKV2D-26 and familial pancreatic carcinoma.