On this subject, a recent study identified a potentially damaging mutation in the DNA Methyltransferase 3 Beta (DNMT3B, 20q11.21, #602900) gene, which is a D4Z4-chromatin modifier and, therefore, it represents a good candidate gene for FSHD [2,18,25]. This evidence concerns the gene DNMT3B and facioscapulohumeral muscular dystrophy.