ISG20 and infection: Three ISG20 mutants lost their ability to inhibit VSV spread in culture (M3, M4 and M2-1, color-coded in purple), while two behaved as wild-type (M2 and M5, color-coded in yellow, Fig 2D, for replication over time in Jurkat T cells and S7A Fig, for a single time point in HeLa cells, 15 hours post infection).