Seemingly consistent with this notion, additional mutations have been found to co-occur with JAK2V617F in the MPN clone, including mutations in TET2, ASXL1, DNMT3A, EZH2 or IDH1/2, which are thought to impact epigenetic regulation and contribute to clonal skewing [55, 56]. Here, ASXL1 is linked to myeloproliferative neoplasm.