Previous studies reported that cytokines and cytokine receptors, the deficiency of which impaired muscle regeneration, also play important roles in stem cell growth and differentiation and can recruit myoblasts for muscle growth.14, 39, 40, 41, 42 Additionally, a previous study reported that histamine has a direct effect on fibroblast proliferation in the ischaemic heart through the histamine/STAT6 signalling pathway in vivo and in vitro.31 Whether the dysfunction of CD11b+ myeloid cells is related to their differentiation or phagocytic ability remains to be investigated in the future. The gene discussed is STAT6; the disease is benign neoplasm.