Recent whole‐exome sequencing of HNSCC samples has identified mutations (10%) and/or amplification (40%) of the gene encoding the catalytic subunit of PI3K (PIK3CA), the gene encoding for p110α subunit of PI3K, making it the most commonly altered oncogene in human HNSCC patients (Iglesias‐Bartolome et al., 2013; Lui et al., 2013; Pickering et al., 2013; The Cancer Genome Atlas, 2013). The gene discussed is PIK3CA; the disease is cancer.