CLOCK and obesity due to melanocortin 4 receptor deficiency: This is supported by genetic models, showing that a defective core clock will lead to, among others, obesity.14 In addition, levels of immune cells and pro‐inflammatory cytokines show daily fluctuations,15 and functionality of the immune system has been linked to the biological clock.16, 17 Consequently, disturbed biological clock function may contribute to atherosclerosis risk through the development of dyslipidemia and a pro‐inflammatory state.