Furthermore, hematopoietic Rev‐erbα knockdown increases atherosclerosis,47 and stimulation of REV‐ERB by agonist treatment reduces atherosclerosis in Ldlr−/− mice.48 In both studies, no effect on plasma cholesterol was observed, but changes in atherosclerosis rather depended on modulation of immune function, similar to our study. This evidence concerns the gene NR1D1 and atherosclerosis.