In IBC, high IDH2 protein expression was associated with positive LVI status (p = 0.002), high histological grade, high Nottingham Prognostic Index (NPI), hormonal receptor negativity, HER2 positivity (all p < 0.0001), large tumour size (p = 0.005), basal phenotype (p = 0.007) and high proliferation index (Ki67) (p = 0.008) (Table 2). This evidence concerns the gene NR4A1 and neoplasm.