Some research has suggested that CRP and IL‐6 could effectively predict clinical outcomes in patients with glioma.6, 10, 11, 12, 13 In contrast, other studies showed no association between these factors and the prognosis of patients with glioma.10, 14, 15, 16 To elucidate the essential relationship between circulating inflammatory factors and the risk of glioma as well as their prognostic values in glioma in clinical practice, we performed this meta‐analysis. Here, IL6 is linked to central nervous system cancer.