CHRNA5 and neoplasm: Two variants in these regions, rs578776 (CHRNA3, OMIM:118503) and rs16969968 (CHRNA5, OMIM:118505), have been associated with both smoking behavior, including smoking quantity, and certain types of neoplasms, for example, HNC (Anantharaman et al., 2014; Changeux, 2010; Lips et al., 2010).