The fact that microbiota composition, and in particular the ratio of Desulfovibrionaceae to Muribaculaceae reflected in the y0 partition, correlated significantly with parameters such as steatosis score, NAFLD activity score, %liver lipid, liver triglycerides, plasma ALT, and Ccl2_Mm00441242 expression reinforces the notion that alterations in the abundance of these bacteria have an impact on histological, biochemical, and gene expression parameters of relevance in NASH. Here, GPT is linked to metabolic dysfunction-associated steatohepatitis.