In randomised studies, immunotherapy with PD-1/PD-L1 (nivolumab, pembrolizumab, atezolizumab and durvalumab) and CTLA4 inhibitors (ipilimumab in combination with nivolumab) is shown to be effective in patients with advanced NSCLC [17]. This evidence concerns the gene CD274 and non-small cell lung carcinoma.