For example there have been reports of mutations in COL21A associated with chondrosarcoma [77], of disparate mutations in glioblastoma [78], of the fusion of α chain type 1 of collagen gene and platelet-derived growth factor β gene in dermatofibrosarcoma protuberans [79], of methylation of the COL1A2 gene and the promoter region of type IV collagen α5 and α6 chains [80], of methylation and silencing of collagen expression in hepatocellular carcinoma cell lines [80], and of methylation of the promoter-5α region of COL1A2 in pancreatic W8 cells [80]. The gene discussed is COL1A2; the disease is hepatocellular carcinoma.