Up to now, by either analysis of a single dataset or integrated analysis of multiple datasets in GEO, several studies have dug out genes that exert important influence on the occurrence and progression of PCa, such as cadherin 1 (CDH1) (Fang et al., 2017), CDCA8 (Zhao et al., 2017), RPS21 (Fan et al., 2018), PIK3R1 (He et al., 2018), epithelial cell adhesion molecule (EPCAM) (Lu & Ding, 2019), LMNB1 (Song et al., 2019b), IGF2 (Tan, Jin & Wang, 2019), and IKZF1 (Tong, Song & Deng, 2019). This evidence concerns the gene CDH1 and posterior cortical atrophy.