Beyond that, some potassium channel related genes (KCNA2, KCNE1B, KCNH1, KCNJ4 and KCNK4) were co-expressed with collagen genes in a way, revealing that collagen genes might be correlated with the regulation of potassium channels in ESCC. The gene discussed is KCNA2; the disease is esophageal squamous cell carcinoma.