Beyond that, some potassium channel related genes (KCNA2, KCNE1B, KCNH1, KCNJ4 and KCNK4) were co-expressed with collagen genes in a way, revealing that collagen genes might be correlated with the regulation of potassium channels in ESCC. This evidence concerns the gene KCNK4 and esophageal squamous cell carcinoma.