EGFR and non-small cell lung carcinoma: The first-generation EGFR TKIs (e.g. gefitinib and erlotinib) bind reversibly and competitively to the ATP-binding site of the EGFR tyrosine kinase (TK) domain, which improves the outcome of NSCLC patients bearing EGFR-activating mutations (L858R and Del19) [7,8].