First degree relative family history of NF2 or unilateral vestibular SCH and 2 of meningioma, cataract, glioma, neurofibroma, SCH, cerebral calcification (if unilateral vestibular SCH + ≥ 2nonintradermal SCHs, need negative LZTR1 gene test). This evidence concerns the gene NF2 and central nervous system cancer.