The GSEA of a c2 a priori defined gene set indicates that mRNA splicing minor pathway, spliceosome, RNA degradation, tumor invasiveness, apoptosis, leiomyosarcoma, homeostatic proliferation, metastasis, NF-KB and Wnt signaling pathway, Kras oncogenic signature, and tumor protein p53 pathway (Figure 14A-P, Table S8) were significantly enriched in groups of PVT1 was overexpressed. This evidence concerns the gene KRAS and leiomyosarcoma.