The oncogene role of PVT1 in cancers have been identified in multiple cancers including bladder cancer 41, nasopharyngeal carcinoma (NPC) 40, colorectal cancers (CRC) 37, non-small-cell lung cancer (NSCLC) 42, 43, clear cell renal cell carcinoma (ccRCC) 36, gastric cancer (GC) 44-46, head and neck squamous cell carcinoma (HNSCC)35, prostate cancer (PC) 34, esophageal squamous cell carcinoma (ESCC) 47, osteosarcoma 48, 49, hepatocellular carcinoma (HCC)50, 51, and pancreatic ductal adenocarcinoma (PDAC) 52. The gene discussed is PVT1; the disease is pachyonychia congenita.