Therefore, we conclude that ondansetron may have an inhibiting effect on PVT1 in sarcoma by regulating HTR1B, whereas, econazole inhibition was through regulating NGB and MB. In addition, because MB is a hub DEG in the WGCNA network of sarcoma tumor tissues, we conclude that econazole plays a role in its suppression mainly through the regulation of MB. However, further experiments are needed to confirm this hypothesis. The gene discussed is PVT1; the disease is sarcoma.