Among them, the Nav1.5 has been shown to be associated with colon cancer and breast cancer metastasis 6, 7; inhibition of Nav1.6 reduced invasiveness of cervical cancer primary culture cells 8; and in prostate cancer, Nav1.8 expression was revealed to be closely correlated with pathologic stage of cancer specimens 9. This evidence concerns the gene SCN8A and malignant colon neoplasm.