SCN5A and malignant colon neoplasm: The voltage-gated Na+ channel has been established to be associated with metastatic cell behavior in cancer 5, 32, 33, several Na+ channel isoforms were identified to be expressed in different cancers, these included Nav1.5 in breast and colon cancers 6, 7, Nav1.6 in cervical cancer 8, and Nav1.8 in prostate cancer 9.