To help elucidate the possible relationship between AKR1B10 expression and HCC outcomes, we identified the AKR1B10 expression in GEO, Oncomine and TCGA databases and performed a survival analysis based on TCGA profile, in the hope of providing useful insights into hepatocarcinogenesis and aggressiveness. This evidence concerns the gene AKR1B10 and hepatocellular carcinoma.