Moreover, subgroup analysis revealed that AKR1B10 upregulation in tumors was risk factor for 1-year, 3-year and 5-year OS in HCC patients (HR = 1.74, log rank P = 0.041; HR = 1.51, log rank P = 0.039 and HR = 1.53, log rank P = 0.021, respectively, Figure 3C - 3E). The gene discussed is AKR1B10; the disease is hepatocellular carcinoma.