For example, MPZL1/PZR was identified as the target gene that plays a pivotal role in HCC tumor metastasis 44; GP96 was reported as an oncogenic chaperone in hepatocytes that promotes hepatocellular carcinogenesis 45; and KLF-4 was demonstrated to be a promising target to treat cancers, including HCC 46. The gene discussed is KLF4; the disease is neoplasm.