Convex-Probe endobronchial ultrasound is used for the diagnosis of central masses/lymphadenopathy and lung cancer staging.8-10 It has been observed that the samples obtained from the needles are efficient for investigation of several genes.11-13 Epidermal growth factor (EGFR), anaplastic lymphoma kinase (ALK), ROS proto-oncogene 1 (ROS1), proto-oncogene B-Raf (BRAF) and programmed death-ligand 1 (PD-L1) can be investigated in the sample of a 21G, 22G and 19G needle that convex- probe EBUS is using 12. This evidence concerns the gene CD274 and lung carcinoma.