FAM181B and early-onset autosomal dominant Alzheimer disease: Fam181b codes for an intracellular protein and is widely and almost exclusively expressed in the brain, showing enrichment in the caudate, cerebellum, cortex, hippocampus, and hypothalamus (https://gtexportal.org/home/), and has been associated with Alzheimer's disease (Herold et al., 2016).