In a similar study, tumors from MMTV/HER2 transgenic female mice were transplanted in immunocompetent syngeneic wild-type FVB females, and mice were imaged for tumor cell death, with NIR700-Annexin V. As described above, groups were treated with vehicle (PBS), trastuzumab, rapamycin, or trastuzumab-rapamycin combination every other day. This evidence concerns the gene ANXA5 and neoplasm.