As shown in Fig. 5c, we found a strikingly increased expression of the M2-related markers, MRC1 and IL10, in tumors originated from TMZ-treated cells admixed with TMZ-EVs in comparison to control (p = 0.0286 for both genes), suggesting that EVs secreted by tumor cells during chemotherapy promote tumor repopulation possibly by acting in tumor macrophages inducing a pro-tumoral phenotype. The gene discussed is MRC1; the disease is neoplasm.