These data demonstrate that oncoproteins including RAS and STAT3 may confer chemoresistance through either induction or inhibition of autophagy, whereas tumor suppressors such as p53 may increase chemosensitivity through induction of autophagy.Animal experiments showed that the tumor growth rate was highly induced by RASV12, but could be signlificantly inhibited by introduction of p53 and STAT3-DN (Fig. 7). The gene discussed is STAT3; the disease is neoplasm.