In C. neoformans, CDA1 seems to be the most critical deacetylase gene during infection—the CDA1 gene is much more highly upregulated during the growth of wild-type KN99 yeast cells in the infected lung than CDA2 or CDA3, and a cda1Δ strain is avirulent, consistent with the hypothesis that differential regulation of CDA1 is the driving force behind its importance during infection (30). This evidence concerns the gene AICDA and infection.