ITGAX and amyotrophic lateral sclerosis: Although expansion and activation of microglia have previously been established in ALS (Zhao et al., 2010; Henkel et al., 2006, 2004; Boillee et al., 2006), we found that spinal cord microglia from SOD1G93A mice expressed higher levels of F4/80 and CD11c as the disease progressed (Fig. S7B), also consistent with previous observations (Chiu et al., 2008).