GNAS and cancer: In total, 392 out of 508 (77.2%) cancer-related genes were identified from 98 blood samples (Fig. 4a), including several previously reporter genes: TP53 (pre vs post: 25.9% vs 5.6%),KRAS (pre vs post: 18.5% vs 5.6%), EGFR (pre vs post: 11.1% vs 5.6%), STK11 (pre vs post: 3.7% vs 4.2%), GNAS (pre vs post: 3.7% vs 9.9%).