Finally, the CAD-associated variants specifically in COL4A1 from Coronary Artery Disease Genome-wide Replication and meta-analysis plus C4D were not associated with TortA, whereas CAD-associated COL4A2 variants are only weakly associated with TortA (Table X in the online-only Data Supplement). The gene discussed is COL4A1; the disease is coronary artery disorder.