COL4A2 and cardiovascular disorder: Previous studies have reported association between COL4A2 and CAD but the TortA-associated variants in COL4A2 in the present study are not associated with cardiovascular disease and similarly COL4A2 variants that are associated with CAD do not appear to be associated with arteriolar tortuosity suggesting that variants in this gene complex may be involved differentially in the pathophysiology of microvascular and macrovascular diseases.