Furthermore, ADC values have also been shown to correspond to tumor markers such as Ki-67, predict survival, and serve as an effective means of monitoring treatment response in PCNSL [12,13,20,21,22,23]; however, these prior studies were limited by smaller sample sizes, using single regions of interests to obtain ADC values rather than using more accurate whole tumor segmentation, and the absence of data on PLWH, a patient population classically affected by PCNSL [22,24]. Here, MKI67 is linked to neoplasm.