As a consequence, deregulation of the IRE1α-XBP1 axis has been reported to account for dysfunctional dendritic cells (DCs) and neutrophils [36], and CHOP is critical for the immune inhibitory activity of tumor-infiltrating myeloid-derived suppressor cells (MDSCs) and of CD8+ T cells [37,38]. The gene discussed is XBP1; the disease is neoplasm.